Voprosy meditsinskoi khimii (ISSN 0042-8809)

L-DOPA test for evaluating in vivo catecholamine biosynthesis in normal persons and persons with different diseases

   
Vasil'ev V.N., Matlina E.A.
PubMed Id: 888397
Year: 1977 vol: 23  issue:3  pages: 332-338
Abstract: Administration of 1-DOPA into healthy persons increased its excretion with urine and elevated the adrenaline secretion. The increase of catecholamines excretion was not observed in aged patients with hypertension; the data obtained suggest that the synthesis of catecholamines with utilization of DOPA was inhibited. In patients with ulcerous disease excretion of 1-DOPA was not increased after its administration, but secretion of catecholamines was decreased during the day time. Under ulcerous disease 1-DOPA appears to be used in process unrelated to synthesis of catecholamines.
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Reference: Vasil'ev V.N., Matlina E.A., L-DOPA test for evaluating in vivo catecholamine biosynthesis in normal persons and persons with different diseases, Voprosy meditsinskoi khimii, 1977, vol: 23(3), 332-338.
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