Voprosy meditsinskoi khimii (ISSN 0042-8809)

Anticomplement activity of native dextrans

Preobrazhenskaia M.E., Danilova N.A.
PubMed Id: 888406
Year: 1977 vol: 23  issue:3  pages: 385-391
Abstract: An anticomplementary activity of native dextrans of various structure was studied among the nine dextrans studied, eight polymers exhibited the anticomplementary activity of variable magnitude; only one dextran, containing 95% of 1--6 links and 2% of 1--2 links was unactive. The highest activity was exhibited by dextrans with high content of 1--2 links; lower activity was observed in dextrans, containing high amount of 1--3 links. The anticomplementary activity was not found in partially hydrolyzed dextrans, containing 90% and more links of the 1--6 type, with molecular weight of 2-10(6) daltons and lower. Polyaldehydes, obtained from these dextrans by oxidation with iodic acid, acquired the anticomplementary activity, comparable with the activity of native dextrans.
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Reference: Preobrazhenskaia M.E., Danilova N.A., Anticomplement activity of native dextrans, Voprosy meditsinskoi khimii, 1977, vol: 23(3), 385-391.