Voprosy meditsinskoi khimii (ISSN 0042-8809)

Hypocholesterolemic effect of hepatic microsomal enzymes in rats

   
Salganik R.I., Manankova N.M., Semenova L.A.
PubMed Id: 919369
Year: 1977 vol: 23  issue:4  pages: 468-473
Abstract: An inductor of microsomal enzymes 9-acetate-16alpha-isothiocyanogen pregnenolone (ATCP), administered into rats within 5 days after termination of feeding with an atherogenic diet, caused normalization of cholesterol content in blood, of beta-lipoproteins spectrum as well as the structure of liver cells. At the same time, in animals, which were not treated with ATCP, high level of cholesterol was maintained in blood serum; reducing smooth endoplasmic reticulum and a decrease in content of glycogen in hepatocytes were also observed. Enzymatic oxidation of cholesterol into 7alpha-hydroxycholesterol, distinctly stimulated by ATCP, appears to be the cause of increased elimination of cholesterol from the organism. ATCP might be used as a drug decreasing the content of cholesterol in blood of patients with hypercholesterolemia.
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Reference: Salganik R.I., Manankova N.M., Semenova L.A., Hypocholesterolemic effect of hepatic microsomal enzymes in rats, Voprosy meditsinskoi khimii, 1977, vol: 23(4), 468-473.
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