Voprosy meditsinskoi khimii (ISSN 0042-8809)

Physico-chemical properties of deamidase AG from Pseudomonas fluorescens AG possessing antitumor activity

   
Rakov S.S., Prozorovskii V.N., Grebenshchikova O.G., Kondrat'eva N.A.
PubMed Id: 411253
Year: 1977 vol: 23  issue:4  pages: 503-508
Abstract: Homogenous deamidase AG from Pseudomonas fluorescens AG was found to be a glycoprotein with molecular weight of about 13,000 daltons. The molecule consists apparently of four similar or identic subunits with molecular weight of about 30,000 daltons. The amino acid composition, N-terminal amino acids, the amount of chymotryptic peptides, containing 14C-carboxymethyl cysteine were studied. The enzyme exhibited distinct antitumoral effect on cells of Burkitt's lymphoma, sensitive to asparaginase, but did not exhibit marked cytotoxic action on cells of human ovarium cancer CaOV line, resistant to asparaginases.
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Reference: Rakov S.S., Prozorovskii V.N., Grebenshchikova O.G., Kondrat'eva N.A., Physico-chemical properties of deamidase AG from Pseudomonas fluorescens AG possessing antitumor activity, Voprosy meditsinskoi khimii, 1977, vol: 23(4), 503-508.
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