Voprosy meditsinskoi khimii (ISSN 0042-8809)

Functional activity of mitochondria and intensity of nucleic acid and protein synthesis in rat liver and small intestine mucosa with different supplies of vitamin D

   
Adrianov N.V., Shuppe N.G., Blazheevich N.V., Spirichev V.B.
PubMed Id: 303409
Year: 1977 vol: 23  issue:4  pages: 537-545
Abstract: Decrease in total content of mitochondrial protein in mucosa of small intestine, an alteration of distribution of the protein between the fractions of mitochondria, distinct decrease in the respiratory activity of mitochondria and in the activity of succinate- and NADH-dehydrogenases were observed in rats deficient in vitamin D. Deficiency in vitamin D was accompanied by decreased incorporation of labelled precursors into total, nuclear and mitochondrial DNA and RNA by 20-50% and into mitochondrial proteins--by 50% in mucosa of small intestine; these patterns were unaltered in liver tissue. Administration of ergocalciferol (at a dose 1000 IU) into rats normalized the impairments studied, whose alteration correlated with the increase of calcium concentration in blood serum.
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Reference: Adrianov N.V., Shuppe N.G., Blazheevich N.V., Spirichev V.B., Functional activity of mitochondria and intensity of nucleic acid and protein synthesis in rat liver and small intestine mucosa with different supplies of vitamin D, Voprosy meditsinskoi khimii, 1977, vol: 23(4), 537-545.
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