Voprosy meditsinskoi khimii (ISSN 0042-8809)

Anion-sensitive nuclear ATPase of the rat heart

Ivashchenko A.T.
PubMed Id: 22954
Year: 1977 vol: 23  issue:5  pages: 629-632
Abstract: Properties of HCO--3-stimulated ATPase from rat heart muscle nuclei were studied. The maximal activity of HCO--3-ATPase was observed at concentration of bicarbonate 25 mM. The enzyme had a pH optimum at pH 8.0-8.5. Bicarbonate stimulated the ATPase activity only in presence of Mg2+, Mn2+ and Zn2+, Co2+, Cd2+ and Ca2+ were ineffective. NaCO3 and Na2SO3 at concentration 30 mM stimulated the nuclear ATPase activity by 20% and 81%, respectively. Anions N3--, scn--, clO--4, and I-- inhibited both Mg2+-ATPase and HCO--3-ATPase. HSO--3 and SO2--4 ions did not affect the nuclear ATPase activity.
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Reference: Ivashchenko A.T., Anion-sensitive nuclear ATPase of the rat heart, Voprosy meditsinskoi khimii, 1977, vol: 23(5), 629-632.