Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of Ca2+ ions on the pyruvate kinase isoenzymes from rabbit kidney cortex

   
Il'in V.S., Kozhevnikova K.A.
PubMed Id: 595501
Year: 1977 vol: 23  issue:5  pages: 653-657
Abstract: Ca2 ions showed the various effect on isoenzymes of pyruvate kinase from rabbit kidney cortex. Ca2 activated the 'L' type of pyruvate kinase at low concentrations of PEP and inhibited -- at high concentrations of the latter. 'M2' type of pyruvate kinase was inhibited by Ca2 under all the conditions studied. In presence of Ca2+ the activating effect of PDP on 'L' and 'M2' types of pyruvate kinase was absent; the inhibitory action of ATP on the 'M' type of pyruvate kinase was increased at all the concentrations above 1.3 mM. The effect of Ca2+ on the pyruvate kinase isoenzymes depended on content of Mg2+ in the medium.
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Reference: Il'in V.S., Kozhevnikova K.A., Effect of Ca2+ ions on the pyruvate kinase isoenzymes from rabbit kidney cortex, Voprosy meditsinskoi khimii, 1977, vol: 23(5), 653-657.
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