Voprosy meditsinskoi khimii (ISSN 0042-8809)

Calcium transport in rabbit myocardial cells during experimental heart damage

   
Grozdova M.D., Sharlova I.L., Starostina L.K.
PubMed Id: 595480
Year: 1977 vol: 23  issue:6  pages: 735-741
Abstract: Content and distribution of 45Ca, administered intravenously, were studied in fractions of rabbit myocardial tissue in experimental allergic and caused by injections of adrenaline heart impairments. Concentration of Ca was increased in mitochondria as well as its binding was stimulated both in mitochondria and in sarcoplasmic reticulum. Increased Ca utilization by mitichondria was also shown in vitro. Correlation between Ca accumulation in mitochondria and energy metabolism impairment in myocardium is discussed. The distinct increase of Ca concentration in mitochondria simultaneously with stabilization of its content in homogenate of myocardial tissue suggest that amount of Ca, bound to myofibrillar proteins, is decreased under the pathological conditions studied.
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Reference: Grozdova M.D., Sharlova I.L., Starostina L.K., Calcium transport in rabbit myocardial cells during experimental heart damage, Voprosy meditsinskoi khimii, 1977, vol: 23(6), 735-741.
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