Voprosy meditsinskoi khimii (ISSN 0042-8809)

Synthesis of multiple forms of brain cholinesterases

   
Rusev G.K., Tomova E.L., Andreeva L.S.
PubMed Id: 595481
Year: 1977 vol: 23  issue:6  pages: 741-745
Abstract: Highly purified multiple forms of brain cholinesterase were isolated by a new method. Eight forms were identified as acetyl cholinesterases, seven forms--as butyryl cholinesterases, four forms--as mixed acetyl- and butyryl cholinesterases and four forms--as aliesterases. Biosynthesis of multiple forms of brain cholinesterase was monitored by following incorporation of 14C-glycine into the purified fractions. Cats were killed at different periods (3 hrs, 3,6 and 9 days) after intoxication with isopropyl hydroxymethyl fluorophosphate. The restoration of the enzymatic activity after the inhibition did not correspond to the incorporation of the labelled amino acid into the enzyme protein. There was a transcient increase in the incorporation of the label after an increase in acetylcholine concentration.
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Reference: Rusev G.K., Tomova E.L., Andreeva L.S., Synthesis of multiple forms of brain cholinesterases, Voprosy meditsinskoi khimii, 1977, vol: 23(6), 741-745.
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