Voprosy meditsinskoi khimii (ISSN 0042-8809)

Erythropoietin-forming and esterase activity of rat kidney subcellular fractions during stimulation of erythropoiesis

   
Novikov N.M., Voronkov S.F., Voloshchenko L.G., Mikhailova S.N.
PubMed Id: 595483
Year: 1977 vol: 23  issue:6  pages: 756-759
Abstract: Stimulation of erythropoiesis in rats (hemolytic-phenylhydrazine and acute posthemorrhagic anemia, effect of hypoxic hypoxia) was accompanied by an increased erythropoietine-formating activity in kidney microsomes and light mitochondria. The phenomenon correlated with an increased esterase activity in hypotonic supernatant of kidney homogenate mainly due to the enzymatic fraction, corresponding to alpha2-globulin by its mobility. Histochemical examination of kidney showed that the most distinct alterations in the esterase activity were observed in epithelial cells of nephron proximal part and in capillary endothelium.
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Reference: Novikov N.M., Voronkov S.F., Voloshchenko L.G., Mikhailova S.N., Erythropoietin-forming and esterase activity of rat kidney subcellular fractions during stimulation of erythropoiesis, Voprosy meditsinskoi khimii, 1977, vol: 23(6), 756-759.
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