Voprosy meditsinskoi khimii (ISSN 0042-8809)

Comparative study of nuclear RNA in leukocytes of normal individuals and patients with leukemia by the method of molecular DNA-RNA hybridization

   
Morozova E.O., Blinov M.N.
PubMed Id: 271418
Year: 1977 vol: 23  issue:6  pages: 812-818
Abstract: Spectra of nuclear RNA were studied in leukocytes in healthy donors and in patients with leukoses by DNA-RNA hybridization. Cross competitive hybridization showed that in chronic lymphoid leukosis and acute myeloblastosis new forms of nuclear RNA were observed, which were not found in normal state; in myeloleukosis the nuclear RNA spectra were similar to those of normal granulocytes. The results obtained suggest that universal type of impairments appears to be absent in regulation of transcription in leukoses; it may be related not only to leukosis transformation but depends on variations in cell content of leukocyte populations studied.
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Reference: Morozova E.O., Blinov M.N., Comparative study of nuclear RNA in leukocytes of normal individuals and patients with leukemia by the method of molecular DNA-RNA hybridization, Voprosy meditsinskoi khimii, 1977, vol: 23(6), 812-818.
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