Voprosy meditsinskoi khimii (ISSN 0042-8809)

Microsomal oxygenase enzyme system during chronic administration of 2-acetylaminofluorene

   
Kobliakov V.A., Koliada A.Yu.
PubMed Id: 96595
Year: 1978 vol: 24  issue:1  pages: 113-118
Abstract: Alteration in content of enzymatic components was studied in microsomal oxygenases system of rats administered with 2-acetyl aminofluorene. Content of cytochrome R-450 was decreased beginning from the fourth week of the experiment. Activity of NADP cytochrome c reductase was higher in animals, treated with the drug as compared with controls. Inductors of the I and II type were capable to induce the enzymatic system up to the end of the experiment - within 16 weeks as far as liver tumors developed.
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Reference: Kobliakov V.A., Koliada A.Yu., Microsomal oxygenase enzyme system during chronic administration of 2-acetylaminofluorene, Voprosy meditsinskoi khimii, 1978, vol: 24(1), 113-118.
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