Voprosy meditsinskoi khimii (ISSN 0042-8809)

New aspects of the effect of isoniazid on transaminase activity in tuberculosis

   
Sodikov E.S., Kazakov K.S.
PubMed Id: 664479
Year: 1978 vol: 24  issue:1  pages: 3-7
Abstract: New evidence is obtained for inhibitory effect of isoniazid on activity of transaminases in prolonged application of the drug. Increase in the isoniazid inhibitory effect on alanine aminotransferase activity was shown to correlate with elevated concentration of Cu2+ in blood serum arising in experimental tuberculosis. Cu2+ and Co2+ caused the increase in the inhibitory effect of isoniazid due to their incorporation into structure of the preparation. The microelements, combined with pyridoxine, inhibited alanine aminotransferase and vice versa activated aspartate aminotransferase.
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Reference: Sodikov E.S., Kazakov K.S., New aspects of the effect of isoniazid on transaminase activity in tuberculosis, Voprosy meditsinskoi khimii, 1978, vol: 24(1), 3-7.
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