Voprosy meditsinskoi khimii (ISSN 0042-8809)

Isolation and analysis of encephalitogenic fractions of spinal cord proteins

   
Zhitnukhin I.L., Pleskov V.M.
PubMed Id: 78578
Year: 1978 vol: 24  issue:1  pages: 57-62
Abstract: Main encephalitogenic protein was isolated from bovine medulla spinalis and separated into homogenous polypeptide fractions by gel filtration; some of these fractions had the high encephalitogenic activity. The main protein and its fractions, possessing the encephalitogenic activity, caused a development of cross-reacting antibodies and a sensitization to intracutaneous administration of encephalitogenic preparations in animals. Non-encephalitogenic main protein sensitized animals only to this protein and did not induce the formation of distinct amount of antibodies. The amino acid composition of the encephalitogenic polypeptide is exhibited.
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Reference: Zhitnukhin I.L., Pleskov V.M., Isolation and analysis of encephalitogenic fractions of spinal cord proteins, Voprosy meditsinskoi khimii, 1978, vol: 24(1), 57-62.
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