Voprosy meditsinskoi khimii (ISSN 0042-8809)

State of the glycolytic system in the hypertrophied heart

Larionov N.P.
PubMed Id: 149427
Year: 1978 vol: 24  issue:1  pages: 7-11
Abstract: A turnover of glycogen was distinctly increased in hypertrophic rat heart within 2 months after coarctation of aorta; this was corroborated by increased 4.5-fold incorporation of 14C-glucose into glycogen and by removing of label from glycogen in heart perfusion using Langendorf preparation. Due to stationary activation of glycolysis secretion of lactate from isolated hypertrophic heart was twice more than that from intact one in aerobic contitions. Activities of glycolytic enzymes, extracted from intact and hypertrophic heart muscles in optimal conditions of incubation, were approximately of the same value; this suggests the distinct potential activity of glycolytic system in myocardium in vivo. Decrease in oxygen utilization is apparently the reason of glycolytic system activation in development of heart hypertrophy.
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Reference: Larionov N.P., State of the glycolytic system in the hypertrophied heart, Voprosy meditsinskoi khimii, 1978, vol: 24(1), 7-11.