Voprosy meditsinskoi khimii (ISSN 0042-8809)

Phospholipid distribution and metabolism in the neurons and neuroglia

Flerov M.A.
PubMed Id: 664442
Year: 1978 vol: 24  issue:2  pages: 174-180
Abstract: Ratio and intensity of metabolism of phospholipid separate fractions were studied in neurons and neuroglia, isolated from brain cortex by differential ultracentrifugation in density gradient of sucrose and Ficoll with the rate of enriching up to 90% and 80%, respectively. Neurons were characterized by the higher ratio of monophosphoinositides and lysophosphatidyl cholines as compared with neuroglia. Content of phosphatide acids and sphingomyelins was higher in neuroglia. The most specific radioactivity was observed in phosphatide acids both in neurons and neuroglia if 2(-14)C-acetate was administered. Neurons were shown to have higher metabolism of the separate fractions of phospholipids.
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Reference: Flerov M.A., Phospholipid distribution and metabolism in the neurons and neuroglia, Voprosy meditsinskoi khimii, 1978, vol: 24(2), 174-180.