Voprosy meditsinskoi khimii (ISSN 0042-8809)

Pathogenesis of hyperlipoproteinemia in rats after the administration of ethanol

   
Titov V.N., Pitsin D.G.
PubMed Id: 664451
Year: 1978 vol: 24  issue:2  pages: 244-252
Abstract: Single administration of ethanol at a dose of 6 g/kg of body weight caused accumulation of triglycerides in rat liver and development of hyperlipoproteinemia. Synthesis of mono-, di-, triglycerides and apoproteins of lipoproteins of very low density was increased in liver tissue. Lipoproteins of very low density were accumulated in blood; their transformation to lipoproteins of low density was impaired and synthesis of high density lipoproteins was decreased. In fatty tissue synthesis of fatty acids was decreased with simultaneous increase in activity of hormone-dependent lipoprotein lipase. Utilization of acetyl CoA pools, formed from exogenous 14C-acetate and 3H-leucine, was dissimilar in synthesis of neutral lipids and phospholipids; the phenomenon demonstrated that acetyl CoA pools were compartmentalized in synthesis of fatty acids.
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Reference: Titov V.N., Pitsin D.G., Pathogenesis of hyperlipoproteinemia in rats after the administration of ethanol, Voprosy meditsinskoi khimii, 1978, vol: 24(2), 244-252.
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