Voprosy meditsinskoi khimii (ISSN 0042-8809)

Importance of the fibrinogen-heparin complex in the fibrinolytic activity of the blood euglobulin fraction after the intravenous administration of thrombin or plasmin

   
Kudriashov B.A., Liapina L.A., Ul'ianov A.M.
PubMed Id: 149422
Year: 1978 vol: 24  issue:2  pages: 255-260
Abstract: Intravenous administration of plasmin as distinct from thrombin inhibited or did not provide a secretion of endogenous heparin into circulation. In these conditions non-enzymatic fibrinolysis was not observed both in fraction of euglobulins and in fibrinogen-heparin complex, isolated from euglobulins, due to insufficiency of heparin. Exogenous heparin, injected into circulation or added to corresponding fractions, enabled to produce the active heparin complexes. About 70% of total fibrinolytic activity was due to fibrinogen-heparin complex in euglobulin fraction of blood plasma, isolated from blood of animals intravenously administered with thrombin.
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Reference: Kudriashov B.A., Liapina L.A., Ul'ianov A.M., Importance of the fibrinogen-heparin complex in the fibrinolytic activity of the blood euglobulin fraction after the intravenous administration of thrombin or plasmin, Voprosy meditsinskoi khimii, 1978, vol: 24(2), 255-260.
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