Voprosy meditsinskoi khimii (ISSN 0042-8809)

Metabolism of myocardial poly A+-containing mRNA normally and in compensatory cardiac hyperfunction

   
Meerson F.Z., Iavich M.P., Gorach G.G.
PubMed Id: 149423
Year: 1978 vol: 24  issue:2  pages: 275-281
Abstract: Two fractions of mRNA--polyA+ and polyA- containing mRNA--were found in rat heart muscle by affinity chromatography using polyU cellulose. These fractions constituted 30% and 70% of total mRNA, respectively. The ratio of polyA+/polyA- mRNA was not altered in myocardium under heart hyperfunction and in physiological ageing. Duration of life of polyA+ containing mRNA was 4 hrs in normal heart. A; the beginning of myocardium hyperfunction the period of mRNA life was decreased down to 2-3 hrs; this pattern of mRNA life alteration did not differ from control one in prolonged heart hypertrophy within 6 months. The rate of polyA+ containing mRNA synthesis was increased by 70% at the early steps of heart hyperfunction as compared with normal state; it decreased below the normal state in long-term hypertrophy of myocardium. In development of heart hyperfunction acceleration of polyA+ containing mRNA synthesis was more distinct than an increase in rRNA synthesis.
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Reference: Meerson F.Z., Iavich M.P., Gorach G.G., Metabolism of myocardial poly A+-containing mRNA normally and in compensatory cardiac hyperfunction, Voprosy meditsinskoi khimii, 1978, vol: 24(2), 275-281.
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