Metabolism of myocardial poly A+-containing mRNA normally and in compensatory cardiac hyperfunction | 
 
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| Meerson F.Z., Iavich M.P., Gorach G.G. | | PubMed Id: 149423 | | Year: 1978 vol: 24 issue:2
pages: 275-281 | | Abstract: Two fractions of mRNA--polyA+ and polyA- containing mRNA--were found in rat heart muscle by affinity chromatography using polyU cellulose. These fractions constituted 30% and 70% of total mRNA, respectively. The ratio of polyA+/polyA- mRNA was not altered in myocardium under heart hyperfunction and in physiological ageing. Duration of life of polyA+ containing mRNA was 4 hrs in normal heart. A; the beginning of myocardium hyperfunction the period of mRNA life was decreased down to 2-3 hrs; this pattern of mRNA life alteration did not differ from control one in prolonged heart hypertrophy within 6 months. The rate of polyA+ containing mRNA synthesis was increased by 70% at the early steps of heart hyperfunction as compared with normal state; it decreased below the normal state in long-term hypertrophy of myocardium. In development of heart hyperfunction acceleration of polyA+ containing mRNA synthesis was more distinct than an increase in rRNA synthesis. | | Download PDF: | | Reference: Meerson F.Z., Iavich M.P., Gorach G.G., Metabolism of myocardial poly A+-containing mRNA normally and in compensatory cardiac hyperfunction, Voprosy meditsinskoi khimii, 1978, vol:
24(2), 275-281. | |
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