Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of eserine on DNA synthesis in rat liver

Elaeva N.L., Stroikov Yu.N.
PubMed Id: 685189
Year: 1978 vol: 24  issue:4  pages: 461-464
Abstract: Incorporation of labelled precursors into total and nuclear DNA of liver tissue was inhibited after administration into animals of eserine at a dose 0.1--0.2 mg/100 g of body weight. Simultaneously, DNAase activity was increased and cholinesterase activity was inhibited in liver tissue. The DNA synthesis was inhibited in liver slices, if they were incubated with 2.10(-6) M eserine. The DNAase activity was unaltered in vitro. A cholinolytic compound metacin, pre-administered into the animals, was ineffective at dose of 1 mg/kg; it slightly decreased the effect of eserine at dose of 0.25 mg/kg.
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Reference: Elaeva N.L., Stroikov Yu.N., Effect of eserine on DNA synthesis in rat liver, Voprosy meditsinskoi khimii, 1978, vol: 24(4), 461-464.