Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in the activity of monoamine oxidase, adenylate cyclase and adenosine triphosphatase in liver cells during the process of hepatocarcinogenesis

   
Gurkalo V.K., Tret'iakov A.V.
PubMed Id: 150700
Year: 1978 vol: 24  issue:4  pages: 495-499
Abstract: Activity of specific mitochondrial enzymes was studied in rat liver during 2-acetylamine fluorene or diethylnitrosamine-induced hepatocancerogenesis. The results of enzymatic activities studied correlated with morphological changes in cancerogenesis. Alterations in activity of monoamine oxidase, adenylate cyclase and adenosine triphosphatase depended on the step of cancerogenesis. Activity of adenylate cyclase in cell membranes decreased gradually during the impairment. Change in activity of the enzymes, observed at the step of enhanced liver cell proliferation, proceeded at further steps of cancerogenesis. The data obtained suggest that alterations in activity of mitochondrial enzymes are related to modified metabolism observed in the impaired cells.
Download PDF:
Reference: Gurkalo V.K., Tret'iakov A.V., Changes in the activity of monoamine oxidase, adenylate cyclase and adenosine triphosphatase in liver cells during the process of hepatocarcinogenesis, Voprosy meditsinskoi khimii, 1978, vol: 24(4), 495-499.
References
 1985(Vol:31)
 1984(Vol:30)
 1983(Vol:29)
 1982(Vol:28)
 1981(Vol:27)
 1980(Vol:26)
 1979(Vol:25)
 1978(Vol:24)
 1977(Vol:23)
 1976(Vol:22)