Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of phosphatidylserine on formation and lysis of fibrin

   
Byshevskiĭ A.Kh., Lapusova T.M., Mukhacheva I.A.
PubMed Id: 150701
Year: 1978 vol: 24  issue:4  pages: 510-514
Abstract: Phosphatidyl serine inhibited non-enzymatic step of fibrin formation (selfassociation of monomeric fibrin). But phosphatidyl serine did not affect the factor XIII activity, the rate of fibrin clot retraction and its tolerance to plasmin. Activity of plasmin was not altered in presence of phosphatidyl serine but influence of slowly acting antiplasmin on plasmin was slightly limited by the lipoid. Due to this phenomenon phosphatidyl serine caused the activation of fibrinolysis in native system (blood plasma). The data obtained support the earlier advanced assumptions on inhibition of thrombin-fibrinogene reaction by phosphatidyl serine.
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Reference: Byshevskiĭ A.Kh., Lapusova T.M., Mukhacheva I.A., Effect of phosphatidylserine on formation and lysis of fibrin, Voprosy meditsinskoi khimii, 1978, vol: 24(4), 510-514.
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