Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of acetylcholine on protein biosynthesis in regions of the heart in adult and old rats

   
Verkhratsky N.S.
PubMed Id: 706261
Year: 1978 vol: 24  issue:5  pages: 648-652
Abstract: Effect of acetylcholine on incorporation of labelled amino acids (14C hydrolysate of chlorella protein) into the free amino acid pool and total protein was studied using slices of auricles, right and left heart ventricles, obtained from 2-month, 8--10 month and 26--28-month old rats. Changes in the intensity of protein biosynthesis were estimated by following relative specific activity (RSA--protein specific activity/free amino acid pool specific activity). Maximal increase in the RSA value was found: in auricles of 2-month old rats in presence of 2.5.10(-4) M acetylcholine, in adult rats--in presence of 1.10(-3) M acetylcholine and in old rats--in presence of 5.10(-4) M acetylcholine; in right ventricle of all age groups--at the concentration of 1.10(-5) M acetylcholine. In left ventricle of all age groups the changes in RSA value were statistically unsignificant. Atropine blocked the stimulating effect of acetylcholine on protein biosynthesis in auricles.
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Reference: Verkhratsky N.S., Effect of acetylcholine on protein biosynthesis in regions of the heart in adult and old rats, Voprosy meditsinskoi khimii, 1978, vol: 24(5), 648-652.
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