Voprosy meditsinskoi khimii (ISSN 0042-8809)

Glycosaminoglycans in the makeup of the lipid-protein complexes of the human aorta

   
Popov A.V., Kuznetsov A.S., Lozovskiĭ V.T.
PubMed Id: 212870
Year: 1978 vol: 24  issue:5  pages: 670-675
Abstract: Lipoprotein complexes were studied in intact parts of human aorta as well as in areas of aorta impaired with atherosclerosis. The arterial walls contained particles, which were similar to pre-beta and beta-lipoproteins as evidenced by immunological properties and by size. At the same time, lipoproteins of the vascular walls differed distinctly from those of blood serum because these former lipoproteins possesed altered electrophoretic mobilities in acetyl cellulose, contained glycosamineglycans, exhibited lower rate of flotation in salt-free solution as compared with the salt-containing solution under conditions of analytical ultracentrifugation. The data obtained suggest that the lipoproteins formed complexes with glycosamineglucans in vascular walls.
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Reference: Popov A.V., Kuznetsov A.S., Lozovskiĭ V.T., Glycosaminoglycans in the makeup of the lipid-protein complexes of the human aorta, Voprosy meditsinskoi khimii, 1978, vol: 24(5), 670-675.
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