Voprosy meditsinskoi khimii (ISSN 0042-8809)

Relationship between aminoglucuronide synthesis in the bodies of white rats and the physico-chemical properties of the substrate

   
Golovenko N.Ya.
PubMed Id: 100967
Year: 1978 vol: 24  issue:5  pages: 676-678
Abstract: In rats 5-substituted 2-aminobenzophenones (R-NH2; CH3; Cl) formed N-glucuronides. Amounts of free substances and of the glucuronyl-conjugates, excreted with the urine, depended on the nature of the radical; the derivatives differed in the values of Hammet's constants, in the lipophility and alkalinity. Estimation of Hammet's constants enabled to find a satisfactory correlation between the physico-chemical properties of the derivatives studied and the amounts of glucuronides excreted with urine.
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Reference: Golovenko N.Ya., Relationship between aminoglucuronide synthesis in the bodies of white rats and the physico-chemical properties of the substrate, Voprosy meditsinskoi khimii, 1978, vol: 24(5), 676-678.
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