Voprosy meditsinskoi khimii (ISSN 0042-8809)

Cyclic 3',5'-AMP metabolism in progressive muscular dystrophy patients

Khokhlov A.P., Malakhovskiĭ V.K.
PubMed Id: 216142
Year: 1978 vol: 24  issue:6  pages: 754-758
Abstract: Concentration of cyclic AMP was distinctly decreased in muscular tissue of patients with Dushenn's myodystrophy. Simultaneously, in patients with the myopathy basal activity of adenylate cyclase as well as activation of the enzyme by adrenaline and sodium fluoride were decreased. As a compensation, activity of phosphodiesterase was also decreased. Content of cAMP, activity and activation of adenylate cyclase were similar to normal state in patients with Erb's and Landuzi--Dejerin's myopathies; activity of phosphodiesterase was increased in the latter impairment. Dissociation constant for binding of cAMP by protein kinases was more than 10-fold decreased in patients with these types of myopathy.
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Reference: Khokhlov A.P., Malakhovskiĭ V.K., Cyclic 3',5'-AMP metabolism in progressive muscular dystrophy patients, Voprosy meditsinskoi khimii, 1978, vol: 24(6), 754-758.