Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of hyperoxia combined with hydrocortisone administration on respiration of rat brain mitochondria

   
Podvigina T.T., Troshikhin G.V.
PubMed Id: 734976
Year: 1978 vol: 24  issue:6  pages: 762-765
Abstract: After exposure of rats in oxygen atmosphere under pressure of 3 kgs/cm2 within 2 hrs phosphorylating respiration, respiratory control and the ratio ADP/O were decreased, while time of phosphorylation was increased in mitochondria of brain cortex. Content of 11-hydroxycorticosteroids was increased in blood plasma. Reaction of adrenal cortex to hyperbaric oxygenation was inhibited, if hydrocortisone was administered into animals within 1 hr before the treatment; in this case the patterns of mitochondrial function studied were similar to normal values.
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Reference: Podvigina T.T., Troshikhin G.V., Effect of hyperoxia combined with hydrocortisone administration on respiration of rat brain mitochondria, Voprosy meditsinskoi khimii, 1978, vol: 24(6), 762-765.
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