Voprosy meditsinskoi khimii (ISSN 0042-8809)

Several kinin system indices in diseases of the thyroid gland

Fesenko V.P., Babalich A.K.
PubMed Id: 581624
Year: 1978 vol: 24  issue:6  pages: 781-786
Abstract: Content of free bradikinin, kininogen and kininase activity were studied using biological methods in blood serum of 112 patients with goiter, of 20 patients with instrangulated hernia and of 21 healthy persons. The patterns studied were similar to normal value in patients with euthyroid goiter and instrangulated hernia. Thyrotoxicosis (63 patients) was accompanied by increase in all the patterns studied and the alterations were most pronounced in severe form of the impairment. Content of kininogen and kininase activity were increased about 2-fold and bradikinin content--5-fold. Content of free bradikinin was increased and kininase activity was decreased in all groups of patient within 1--3 days after the operation. Content of kininogen was increased in euthyroid goiter and decreased in thyrotoxic one. Patterns of kinine system trended to normalization within 6 days after the operation.
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Reference: Fesenko V.P., Babalich A.K., Several kinin system indices in diseases of the thyroid gland, Voprosy meditsinskoi khimii, 1978, vol: 24(6), 781-786.