Voprosy meditsinskoi khimii (ISSN 0042-8809)

Acrylonitrile stimulation of lipid peroxidation in rat liver

   
Ivanov V.V., Kuznetsova G.P., Archakov A.I.
PubMed Id: 734985
Year: 1978 vol: 24  issue:6  pages: 816-818
Abstract: Acrylonitrile stimulated slightly the lipid peroxidation in isolated microsomes and exhibited distinct prooxidative effect in postmitochondrial supernatant, containing microsomes and cell juice. Acrylonitrile did not form a complex with cytochrome P-450, possessing distinct spectral properties of the I or II types, and did not stimulate the oxygen utilization by microsomes in presence of NADPH. The hepatotoxic effect of acrylonitrile appears to be due to its property to stimulate the formation of lipid peroxides in hepatocytes.
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Reference: Ivanov V.V., Kuznetsova G.P., Archakov A.I., Acrylonitrile stimulation of lipid peroxidation in rat liver, Voprosy meditsinskoi khimii, 1978, vol: 24(6), 816-818.
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