Voprosy meditsinskoi khimii (ISSN 0042-8809)

Glucose-6-phosphate transformation in the tissues of animals which have received high doses of hydroxythiamine or thiamine

   
Lashak L.K., Trebukhina R.V., Ostrovskiĭ I.M.
PubMed Id: 32658
Year: 1978 vol: 24  issue:6  pages: 822-826
Abstract: Administration of hydroxythiamin or thiamin into rats at a dose 400 mg/kg body weight caused a single-directed (unspecific, nonenzymatic) effect on the activity of glucose-6-phosphate and 6-phosphogluconate dehydrogenases within short periods (3-12 hrs). Within 24 and 72 hrs the effects of vitamin and antivitamin acquired the opposite (specific) direction towards the activity of glucose-6-phosphate dehydrogenase in liver tissues. Content of glucose-6-phosphate was altered depending on time of hydroxythiamin effect. Reverse correlation between the activity of glucose-6-phosphate dehydrogenase and content of the substrate was observed in heart muscle either after administration of hydroxythiamin or thiamin; the phenomenon suggest that dehydrogenase reactions affect considerably the regulation of glucose-6-phosphate content in the tissue.
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Reference: Lashak L.K., Trebukhina R.V., Ostrovskiĭ I.M., Glucose-6-phosphate transformation in the tissues of animals which have received high doses of hydroxythiamine or thiamine, Voprosy meditsinskoi khimii, 1978, vol: 24(6), 822-826.
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