Voprosy meditsinskoi khimii (ISSN 0042-8809)

Metabolism of L-albizziin in rat liver slices

   
Fitsner A.B.
PubMed Id: 734988
Year: 1978 vol: 24  issue:6  pages: 832-836
Abstract: During incubation of rat liver slices with L-albizziin (L-alpha-amino-beta-ureidopropionic acid) formation of the UV-absorbing compound was observed. This compound was isolated from the incubating medium; it possessed two peaks of maximal absorption--at 206-207 nm and 264-265 nm, but a single minimal value at 242-243 nm. The presence of ribose as a constituent of the UV-absorbing compound was demonstrated. Two possible mechanisms explaining formation of the UV-absorbing compound were proposed: 1) metabolic conversion of L-albizziin, and 2) inhibition of purine biosynthesis de novo. The latter mechanism appears to be more probable.
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Reference: Fitsner A.B., Metabolism of L-albizziin in rat liver slices, Voprosy meditsinskoi khimii, 1978, vol: 24(6), 832-836.
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