Voprosy meditsinskoi khimii (ISSN 0042-8809)

Micromethod of preparing and purifying labeled 4-methyl-5-beta-hydroxyethylthiazole

Filippova L.B., Rozanov A.Ya.
PubMed Id: 425367
Year: 1979 vol: 25  issue:1  pages: 102-106
Abstract: A micromethod is developed for production and purification of small amounts (50-60 microgram) of 35S-4-methyl-5beta-hydroxyethyl thiazole(hemineurine)--a neurotropic agent, which is promising for treatment of delirium tremens. 35S-hemineurine was obtained as follows: sulfite separation of it from pyrimidine residues and other reagents py paper electrophoresis and the subsequent elution of labelled 4-methyl-5beta-hydroxyethyl thiazole from electrophoregramms. The purity of the preparation obtained was controlled by chromatographic, chemical and spectrophotometric analysis (using pure unlabelled preparation).
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Reference: Filippova L.B., Rozanov A.Ya., Micromethod of preparing and purifying labeled 4-methyl-5-beta-hydroxyethylthiazole, Voprosy meditsinskoi khimii, 1979, vol: 25(1), 102-106.