Voprosy meditsinskoi khimii (ISSN 0042-8809)

Formation of a heparin-prothrombin complex

Liapina L.A., Strukova S.M., Kudriashov B.A.
PubMed Id: 425371
Year: 1979 vol: 25  issue:1  pages: 41-46
Abstract: Formation of complex between heparin and prothrombin was shown using a spectral method. A method is developed for production of active complex heparin-prothrombin with the ratio of components as 1 : 6. The heparin-prothrombin complex obtained exhibited the anticoagulant and antipolymerization properties as well as the nonenzymatic fibrinolytic effect on instabilized fibrin both in absence and in presence of such blocking agents of enzymatic fibrinolysis as epsilon-aminocapronic acid and soybean inhibitor of trypsin. The increase in the anticoagulant and nonenzymatic fibrinolytic properties of blood occurred after intravenous administration of the complex into animals. The heparin-prothrombin complex acted in circulation within 1.5--2 hrs.
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Reference: Liapina L.A., Strukova S.M., Kudriashov B.A., Formation of a heparin-prothrombin complex, Voprosy meditsinskoi khimii, 1979, vol: 25(1), 41-46.