Voprosy meditsinskoi khimii (ISSN 0042-8809)

mRNA degradation in membrane-bound and free polyribosomes in rat liver cells after exposure to actinomycin D and cycloheximide

   
Arbusov V.A.
PubMed Id: 425372
Year: 1979 vol: 25  issue:1  pages: 62-67
Abstract: Actinomycin D caused degradation of mRNA both in membrane-bound and in free polyribosomes from rat liver cells. The rate of mRNA destruction was distinctly higher in free polyribosomes, than in membrane-bound ones. Cycloheximide inhibited the mRNA destruction in both types of polyribosomes. At the same time, the stabilizing effect of cycloheximide on mRNA was less distinct in free polyribosomes. A decrease in specific radioactivity of mRNA from membrane-bound and free polyribosomes was observed after prolonged pretreatment with actinomycin D. The specific radioactivity of mRNA from polyribosomes of both types was not altered after simultaneous administration of actinomycin D and cycloheximide into rats. Occurence of two fractions of mRNA, dissimilar in stability, is possible both in membrane-bound and in free polyribosomes from rat liver cells.
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Reference: Arbusov V.A., mRNA degradation in membrane-bound and free polyribosomes in rat liver cells after exposure to actinomycin D and cycloheximide, Voprosy meditsinskoi khimii, 1979, vol: 25(1), 62-67.
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