Voprosy meditsinskoi khimii (ISSN 0042-8809)

Inhibitory effect of liquor cerebrospinalis of the activity of Na, Ka-ATPase from mammalian brain synaptic membranes

   
Rozhanets V.V., Promyslov M.Sh., Gabrielian N.I., Shcherbaneva O.I.
PubMed Id: 218361
Year: 1979 vol: 25  issue:1  pages: 71-74
Abstract: Liquor cerebrospinalis, obtained from patients with various diseases, inhibited Na, K-ATPase from rat and bovine synaptic membranes and did not influence on the activity of Mg-ATPase. The inhibition was independent on the type of disease. The inhibitory effect of liquor cerebrospinalis disappeared after dyalisis of it against Krebs-Ringer solution. Liquor cerebrospinalis appears to contain an endogenous inhibitor of synaptic Na,K-ATPase, which controls the enzymatic activity in vivo
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Reference: Rozhanets V.V., Promyslov M.Sh., Gabrielian N.I., Shcherbaneva O.I., Inhibitory effect of liquor cerebrospinalis of the activity of Na, Ka-ATPase from mammalian brain synaptic membranes, Voprosy meditsinskoi khimii, 1979, vol: 25(1), 71-74.
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