Voprosy meditsinskoi khimii (ISSN 0042-8809)

Disorders of oxidative deamination of biogenic amines in the myocardium in experimental atherosclerosis

   
Brusova E.G., Krivchenkova R.S.
PubMed Id: 442591
Year: 1979 vol: 25  issue:2  pages: 198-204
Abstract: Statistically significant inhibition of oxidative deamination of several biogenic amines was found in mitochondrial fraction of heart muscle from rabbits and rats with experimental atherosclerosis and hypercholesterolemia, caused by various methods. Sensitivity of oxidative deamination of tryptamine to inhibitory effect of clorgyline (selective inhibitor of mitochondrial monoamine oxidases) was unaltered in rats with experimental hypercholesterolemia. The rate of oxidative deamination of beta-phenyl ethylamine, tryptamine, benzylamine as well as histamine and putrescine was inhibited after treatment of the mitochondrial fragments from healthy rabbit and rat heart muscles with preparations of oxidized linoleic and linolenic acids, concentration of which was increased in tissues under conditions of atherosclerosis
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Reference: Brusova E.G., Krivchenkova R.S., Disorders of oxidative deamination of biogenic amines in the myocardium in experimental atherosclerosis, Voprosy meditsinskoi khimii, 1979, vol: 25(2), 198-204.
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