Voprosy meditsinskoi khimii (ISSN 0042-8809)

Selection of preparations with anticipated antiestrogen activity

Minina L.S.
PubMed Id: 452493
Year: 1979 vol: 25  issue:3  pages: 283-285
Abstract: Specificity of interaction between estrogen-receptor systems of guinea pig uterus and oviducts and six estrogens was studied. The obtained datas suggest existence of tissue specificity in estrogen-receptor interaction in uterus and oviducts. Modifications of the steroid molecule led to decrease in extent of estrogen affinity. Introduction of an ethyl group into 17 alpha-position resulted in the effect, by the rate of estrogen-receptor binding equal to reduction of 17 beta-hydroxyl. Low but distinct affinity of 17 alpha-estradiol, its structure and stability, enabled to select this substance as a preparation with anticipated anti-estrogenic activity
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Reference: Minina L.S., Selection of preparations with anticipated antiestrogen activity, Voprosy meditsinskoi khimii, 1979, vol: 25(3), 283-285.