Voprosy meditsinskoi khimii (ISSN 0042-8809)

Preparation of monospecific antibodies to A-protein and an immunochemical study of its distribution in normal and tumorous tissues

   
Bannikov G.A., Chipysheva T.A.
PubMed Id: 452495
Year: 1979 vol: 25  issue:3  pages: 292-297
Abstract: Monospecific antibodies against A-protein from rat liver cytosol were prepared. Complete nonidentity was established in comparison of the A-protein and ligandin, which was similar to A-protein in binding properties. Besides, A-protein found in cytosol of liver tissue was present in cytosol of small intestine. It was not found in the cytosol of other 17 tissues. A-protein appeared in ontogenesis earlier than ligandin: its concentration sharply increased in rat embryonal liver within 16--18 day of gestation. Level of A-protein was decreased 2--4-fold in primary rat hepatomas. A-protein and ligandin are the isoforms of binding proteins, which characterize different steps of the differentiation of the hepatocytes
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Reference: Bannikov G.A., Chipysheva T.A., Preparation of monospecific antibodies to A-protein and an immunochemical study of its distribution in normal and tumorous tissues, Voprosy meditsinskoi khimii, 1979, vol: 25(3), 292-297.
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