Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of Krebs cycle oxidative enzymes in the brain in hypothermia

   
Volzhina-Atabegova N.G.
PubMed Id: 452497
Year: 1979 vol: 25  issue:3  pages: 308-311
Abstract: Cooling of rats down to the rectal temperature of 33--35 degrees without the use of narcotic and neuroplegic drugs did not cause distinct alterations in activity of the oxidative enzymes of tricarboxylic acid cycle--isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate-, succinate- and pyruvate dehydrogenases in brain tissue. At the same time, inhibition of the activity of these dehydrogenases occurred in profound hypothermia (cooling to 19--20 degrees). In this case the activity of succinate dehydrogenase was decreased less distinctly as compared with the activity of NAD-dependent dehydrogenases. Succinic acid appears to be an especially important substrate for oxidation in brain of the chilled rats
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Reference: Volzhina-Atabegova N.G., Activity of Krebs cycle oxidative enzymes in the brain in hypothermia, Voprosy meditsinskoi khimii, 1979, vol: 25(3), 308-311.
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