Voprosy meditsinskoi khimii (ISSN 0042-8809)

Hepatotoxicity of the lipid components of the lipopolyysaccharides from typhoid bacteria

   
Muzhichenko A.V., Nikolskaya O.N., Khardina G.A.
PubMed Id: 452500
Year: 1979 vol: 25  issue:3  pages: 319-322
Abstract: Distinct increase in amount of total lipids occurred in mice liver tissue after intraperitoneal administration of typhoid lipids A and B (the latter was nonhydrolytically isolated from typhoid lipopolysaccharides). The alteration referred primarily to neutral lipids, especially to triacyl glycerides, content of which exceeded 3- and more-fold the initial one to the end of a day. The similarity was observed in alteration of triacyl glycerides, phospho- and glycolipids in presence of both lipid preparations. These lipid components resembled intact lipopolysaccharide from typhoid bacteria in their effect on content of lipids in liver tissue. In treatment with these lipid preparations concentration of NEFA was either unaltered or distinctly decreased
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Reference: Muzhichenko A.V., Nikolskaya O.N., Khardina G.A., Hepatotoxicity of the lipid components of the lipopolyysaccharides from typhoid bacteria, Voprosy meditsinskoi khimii, 1979, vol: 25(3), 319-322.
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