Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of deficient and excess thiamine on the lipid makeup of the rat liver plasma membranes

   
Sevostianov A.N.
PubMed Id: 494533
Year: 1979 vol: 25  issue:5  pages: 520-524
Abstract: Single administration of thiamin at a high dose (40 mg) 100 g of body weight into rats led to an increase in content of phospholipids in liver plasmatic membranes; cholesterol and the ratio between phospholipid fractions were unaltered. Maintaining of rats on a rice diet (dietary B1-avitaminosis) as well as a single administration of hydroxythiamin into animals at doses 10 mg and 40 mg per 100 g of body weight did not affect the content of cholesterol and phospholipids in liver plasmatic membranes. At the same time, the ratio of the phospholipid fraction was altered in plasmatic membranes: in dietary B1-avitaminosis content of lecithin was decreased and the content of lysolecithin was increased, high of hydroxythiamin decreased the content of sphingomyelin. Hydroxythiamin at a dose of 10 mg/kg of body weight did not affect these patterns.
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Reference: Sevostianov A.N., Effect of deficient and excess thiamine on the lipid makeup of the rat liver plasma membranes, Voprosy meditsinskoi khimii, 1979, vol: 25(5), 520-524.
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