Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of chemical hepatic carcinogens and noradrenaline on the nucleoside phosphokinase activity of liver cells

   
Gurkalo V.K., Tretyakov A.V.
PubMed Id: 227170
Year: 1979 vol: 25  issue:5  pages: 540-543
Abstract: Distinct increase in activity of uridine kinase and pronounced decrease in thymidine kinase activity were observed in cell-free extracts of rat liver tissue at early stages of hepatocarcinogenesis caused by administration of N-nitrose diethylamine and 2-acetyl aminofluorene. Exogenous noradrepaline did not affect the altered activity of thymidine kinase but stimulated the effect of N-nitrose diethylamine and lowered the effect of 2-acetyl aminofluorene on the urindine kinase activity. Adrenergic neurotransmitters appear to influence the cell proliferation due to modification of the enzymes participating in the synthesis of nucleic acid precursors
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Reference: Gurkalo V.K., Tretyakov A.V., Effect of chemical hepatic carcinogens and noradrenaline on the nucleoside phosphokinase activity of liver cells, Voprosy meditsinskoi khimii, 1979, vol: 25(5), 540-543.
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