Voprosy meditsinskoi khimii (ISSN 0042-8809)

Enzymatic activity in the enterolysed portions of the human gastric mucosa in peptic ulcer and the effect of bile

   
Ivanov G.G.
PubMed Id: 516530
Year: 1979 vol: 25  issue:6  pages: 691-694
Abstract: Activities of lactate dehydrogenase /LDH/, glucose-6-phosphate dehydrogenase /G6PD/, transaminases, alkaline phosphatase as well as content of lactic acid were studied in enterolysed parts of gastric mucose and in normal mucose. The LDH activity and content of lactic acid were decreased in the enterolysed mucose. As compared with normal mucose the activity of G6PD was increased 3-fold, activities of alkaline phosphatase and of glutamine-alanine transaminases were increased 1.5-2-fold in the mucose regions with metaplasia. In vitro glycocholic acid and products of duodenal secretion inhibited distinctly G6PD and LDH within 10 min of incubation; maximal activity of G6PD was observed within 20 min, after addition of cholic acid the enzyme was completely inactivated within 30 min. Under these conditions the activity of alkaline phosphatase was decreased within 10 min and returned up to the initial level within the subsequent periods
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Reference: Ivanov G.G., Enzymatic activity in the enterolysed portions of the human gastric mucosa in peptic ulcer and the effect of bile, Voprosy meditsinskoi khimii, 1979, vol: 25(6), 691-694.
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