Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of alpha-tocopherol on the enzymatic activity of phospholipid biosynthesis and breakdown in burn injury

   
Mkhitarian V.G., Agadzhanov M.I., Kazarian P.A.
PubMed Id: 516532
Year: 1979 vol: 25  issue:6  pages: 698-704
Abstract: Burns affected the content of L-alpha-glycerophosphate /L-alpha-GP/ in rats; its level was reduced within 15 days after burns. Phasic changes in L-alpha-glycerophosphate dehydrogenase and glycerokinase activities in liver and brain tissues and phospholipase A in blood were also observed. Intraperitoneal administration of alpha-tocopheryl acetate into rats subjected to burns abolished the decrease in content of L-alpha-GP although the activity of the drug varied within this 15 day period. In brain the activity of these enzymes was increased 2-3-fold. The data obtained are in good agreement with those published previously and indicating loss of phospholipids in liver and brain tissus following burns
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Reference: Mkhitarian V.G., Agadzhanov M.I., Kazarian P.A., Effect of alpha-tocopherol on the enzymatic activity of phospholipid biosynthesis and breakdown in burn injury, Voprosy meditsinskoi khimii, 1979, vol: 25(6), 698-704.
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