Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of 1,4-benzodiazepine tranquilizers on the activity of the hepatocyte hydroxylating complex and glucose-6-phosphatase in white rats

   
Golovenko N.Ya., Orliuk E.I.
PubMed Id: 42217
Year: 1979 vol: 25  issue:6  pages: 728-731
Abstract: Intraperitoneal administration of diazepame and phenazepame into rats /at a dose 50 mg/kg/ within 4 days did not induce liver microsomal enzymes. After administration of chlordiazepoxide at the same dose content of cytochrome P-450 was increased and the rate of dimethylaniline demethylation was elevated. Content of protein as well as NADPH-cytochrome-c-reductase and glucose-6-phosphatase activities were increased after intraperitoneal administration of all the preparations at a dose 100 mg/kg within 4 days. Experiments on the potentiation of hexenal effect demonstrated the decrease in the time of sleep in animals, treated with chlordiazepoxide at a dose 100 mg/kg of body weight
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Reference: Golovenko N.Ya., Orliuk E.I., Effect of 1,4-benzodiazepine tranquilizers on the activity of the hepatocyte hydroxylating complex and glucose-6-phosphatase in white rats, Voprosy meditsinskoi khimii, 1979, vol: 25(6), 728-731.
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