Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of pyridoxal phosphate and pantothenate derivatives on gamma-aminobutyric shunt in the brain of mice

   
Rozanov V.A.
PubMed Id: 7368625
Year: 1980 vol: 26  issue:1  pages: 42-46
Abstract: Repeated administration of D-pantothenate Ca, D-homopantothenate Ca and pantethine at a dose of 150 mmole/kg of body weight (9 injections within 3 days) led to alterations in activity of GABA-shunt enzymes as well as in content of free amino acids in mouse brain. These alterations suggest that B3-vitamin preparations potentiate the regulating effect on gamma-aminobutyrate pathway, which shunts the alpha-ketoglutarate dehydrogenase reaction, depending on CoA content. The most distinct but short-term intesification of the GABA-shung was observed in treatment with homopantothenate containing GABA molecule. Pantothenate and pantethine caused similar alterations, consisting in activation of GABA production and in inhibition of its utilization; in this case pantethine was less effective. Pyridoxal phosphate activated GABA-shunt; this resulted in accelerated decrease in content of dicarboxylic amino acids and their amides.
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Reference: Rozanov V.A., Effect of pyridoxal phosphate and pantothenate derivatives on gamma-aminobutyric shunt in the brain of mice, Voprosy meditsinskoi khimii, 1980, vol: 26(1), 42-46.
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