Voprosy meditsinskoi khimii (ISSN 0042-8809)

Enzymatic activity of the glycolytic and pentosemonophosphate pathways of carbohydrate conversion in the heart in hypertrophy

   
Denisov V.M.
PubMed Id: 6445126
Year: 1980 vol: 26  issue:1  pages: 51-55
Abstract: In myocardial hypertrophy activity of hexokinase was decreased in heart mitochondria and increased in the supernatant obtained after precipitation of the mitochondria. Activities of phosphofructokinase and fructose diphosphate aldolase were decreased within the acute period of hyperfunction and hypertrophy of myocardium. Under these conditions pentosemopophosphate shunt of carbohydrate metabolism was activated as indicated by the increase in glucose-6-phosphate dehydrogenase activity; the enzyme activity was decreased during the period of hypertrophy atabilization. Possible causes of alteration in the activity of the enzymes of carbohydrate metabolism under conditions of heart hypertrophy are discussed.
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Reference: Denisov V.M., Enzymatic activity of the glycolytic and pentosemonophosphate pathways of carbohydrate conversion in the heart in hypertrophy, Voprosy meditsinskoi khimii, 1980, vol: 26(1), 51-55.
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