Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in lactate dehydrogenase activity and lactic and pyruvic acid concentration in the blood and tissues of animals following intravenous administration of perfluorotributylamine emulsions

   
Afonin N.I., Doronina N.N., Smelova O.S., Ivanova N.L., Putiatina T.K.
PubMed Id: 7456348
Year: 1980 vol: 26  issue:2  pages: 185-187
Abstract: Activity of lactate dehydrogenase (LDH) and concentration of lactate and pyruvate were studied in rat and cat tissues after infusion of perfluorotributylamine emulsion. Administration of the emulsion caused an increase in content of lactate and pyruvate as well as LDH activation in the animal blood and tissues. Tissue hypoxia, responsible for stimulation of glycolytic pathway of carbohydrate metabolism, was apparently developed due to transfer of inadequate amount of oxygen by perfluorotributylamine.
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Reference: Afonin N.I., Doronina N.N., Smelova O.S., Ivanova N.L., Putiatina T.K., Changes in lactate dehydrogenase activity and lactic and pyruvic acid concentration in the blood and tissues of animals following intravenous administration of perfluorotributylamine emulsions, Voprosy meditsinskoi khimii, 1980, vol: 26(2), 185-187.
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