Voprosy meditsinskoi khimii (ISSN 0042-8809)

Selective activation of DNA biosynthesis in rat kidneys following ethyleneimine administration

   
Orlov A.S.
PubMed Id: 7456353
Year: 1980 vol: 26  issue:2  pages: 232-236
Abstract: Selective activation of RNA and DNA synthesis in response to ethylene imine accompanied by subsequent corresponding increase in amount of the nucleic acids, was found in rat kidney. Maximal efficiency of ethylene imine was manifested after administration of non-lethal doses 2.4 mg/kg; lethal doses of the poison were not effective. The alterations were characteristic for both young and adult animals. Similar phenomenon was not detected either in tissues with rapid renewal of cells (thymus, spleen) or in other tissues (liver, lungs).
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Reference: Orlov A.S., Selective activation of DNA biosynthesis in rat kidneys following ethyleneimine administration, Voprosy meditsinskoi khimii, 1980, vol: 26(2), 232-236.
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