Voprosy meditsinskoi khimii (ISSN 0042-8809)

Autolytic changes in serum lipids of normal rats and following acute oxygen deficiency

   
Sergeev S.A., Gribanov G.A.
PubMed Id: 7456357
Year: 1980 vol: 26  issue:2  pages: 260-264
Abstract: Alterations in content of main classes of lipids and phospholipids were studied in blood serum during autolysis in normal rats and in acute oxygen deficiency. In the control animals the most distinct alterations were found in content of phospholipids, which was decreased down to 1/2 of the initial level within 24 hrs of autolysis with simultaneous increase in concentration of fatty acids within 10 hrs. A decrease in content of free cholesterol together with an increase in concentration of its esters were observed in hypoxic animals within 24 hrs of autolysis. During autolysis concentration of phosphatidylcholines was decreased both in control and hypoxic animals. At the same time, an increase in lysophosphatides within 4 hr of autolysis and a decrease in concentration of phosphatidic acids within 24 hrs were found in the control group. In animals with hypoxia phosphatidic acids were only slightly increased and polyglycerophosphatides were found during subsequent periods of autolysis.
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Reference: Sergeev S.A., Gribanov G.A., Autolytic changes in serum lipids of normal rats and following acute oxygen deficiency, Voprosy meditsinskoi khimii, 1980, vol: 26(2), 260-264.
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